WEKO3
アイテム
Synthesis of the Disaccharides of Phenolic Glycolipid I of Mycobacterium leprae with Some Kinds of Aglycone and Their Serological Activities
https://nara-u.repo.nii.ac.jp/records/2001398
https://nara-u.repo.nii.ac.jp/records/2001398a14c3bce-f112-4763-83c0-2ae3ca33aaee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Synthesis of the Disaccharides of Phenolic Glycolipid I of Mycobacterium leprae with Some Kinds of Aglycone and Their Serological Activities
|
|
| アイテムタイプ | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2011-02-17 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Synthesis of the Disaccharides of Phenolic Glycolipid I of Mycobacterium leprae with Some Kinds of Aglycone and Their Serological Activities | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||
| 著者 |
藤原,剛
× 藤原,剛
× 和泉,真蔵
|
|||||||||||||
| 所属 | ||||||||||||||
| 値 | 教養部 | |||||||||||||
| 所属 | ||||||||||||||
| 値 | 教養部 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | The bromide of the peracetate of the non-reducing-end disaccharide of phenolic glycolipid I of Mycobacterium leprae was coupled with lauryl alcohol or 3-phenylpropanol in acetonitrile in the presence of mercury cyanide. The product was the 1:1 mixture of α-and β-1inked disaccharides. The coupling of the bromide with stearyl alcohol in nitromethane-toluene gave mainly α―linked stearyl disaccharide. The complete loss of the stereoselectivity in acetonitrile was thought to be due to the lack of neibouring group participation.\nThe activities of these disaccharides and some other synthetic disaccharides \nwere tested in ELISA inhibition assay and direct ELISA. No compound tested in this study showed lower activity than free disaccharide in ELISA inhibition assay. Among the tested disaccharides, the compounds with long lipophilic chain as lauryl and stearyl disaccharides showed high activity in both ELISA inhibition assay and direct ELISA. On the other hand the compounds with short chain showed only the same level of the activity as that of free disaccharide in ELISA inhibition assay. And these compounds showed no activity in direct ELISA. These results suggest that long lipophilic compounds like lauryl or stearyl alcohol should be chosen for the development of the synthetic antigen convenient for direct ELISA. | |||||||||||||
| 書誌情報 |
奈良大学紀要 Memoirs of the Nara University 号 16, p. 1-10, 発行日 1987-12-01 |
|||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 奈良大学 | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | PISSN | |||||||||||||
| 収録物識別子 | 03892204 | |||||||||||||
| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | Departmental Bulletin Paper | |||||||||||||
